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好消息!科学家研发出了可以杀死癌细胞的转基因病毒

青岛希尼尔翻译咨询有限公司(www.joshualeeproperties.com)整理发布  2018-11-24

  

青岛希尼尔翻译公司(www.joshualeeproperties.com)2018年11月24日了解到:A genetically modified virus that kills cancer cells and destroys their hiding places has been developed by British scientists.

英国科学家研制了出一种转基因病毒,可以杀死癌细胞并摧毁癌细胞的藏身之处。

It targets both cancer cells and healthy cells that are tricked into protecting the cancer from the immune system.

它的目标是癌细胞和被诱骗;ぐ┲⒚馐苊庖呦低成撕Φ慕】迪赴。

The role of fibroblasts is to hold different types of organs together but they can get hijacked by cancer cells to become cancer-associated fibroblasts or CAFs.

成纤维细胞的作用是将不同类型的器官聚集在一起,但它们可能被癌细胞劫持,成为与癌症有关联的成纤维细胞。

These are then known to help tumors grow, spread and evade therapy.

这些癌变的成纤维细胞可以帮助肿瘤生长、扩散和逃避治疗。

The virus, developed by Oxford University scientists, attacks carcinomas, which are the most ?common type of cancer. The findings were published in Cancer Research.

由牛津大学科学家研发的病毒?可以攻击恶性肿瘤,这是常见的一种癌症。研究结果发表在《癌症研究》杂志上。

Currently, any therapy that kills the ‘tricked’ fibroblast cells may also kill fibroblasts throughout the body – for example in the bone marrow and skin – causing toxicity.

目前,任何杀死“被诱骗”的成纤维细胞的疗法都可能杀死全身,例如骨髓和皮肤里的成纤维细胞,产生毒性。

So researchers used a virus called enadenotucirev, which is already in clinical trials for treating carcinomas.

因此研究人员使用了一种名为enadenotucirev的病毒,这种病毒已经用于治疗癌症的临床试验。

It has been bred to infect only cancer cells, leaving healthy cells alone.

它被培育成只感染癌细胞,而不感染健康细胞。

Lecturer Dr. Kerry Fisher also from the Department of Oncology who led the research said: “Even when most of the cancer cells in a carcinoma are killed, fibroblasts can protect the residual cancer cells and help them to recover and flourish.”

带领这项研究的肿瘤科讲师克里.费舍尔博士说:“即使恶性肿瘤的大多数癌细胞被杀死,(被诱骗的)成纤维细胞也能;なS嗟陌┫赴,帮助它们恢复和生长!

“Until now, there has not been any way to kill both cancer cells and the fibroblasts protecting them at the same time, without harming the rest of the body.”

“到目前为止,在不伤害身体其他部位的情况下,还没有一种方法可以同时杀死癌细胞和;ぐ┫赴某上宋赴。

“Our new technique to simultaneously target the fibroblasts while killing cancer cells with the virus could be an important step towards reducing immune system suppression within carcinomas and should kick-start the normal immune process.”

“我们的新技术可以用病毒杀死癌细胞的同时锁定成纤维细胞,这是减少恶性肿瘤免疫系统抑制,启动正常免疫过程的重要一步!

It was tested in human cancer samples and in mice.

该病毒在人类癌症样本和小鼠中进行了测试。

The virus could be tested in humans with carcinomas as early as next year.

这种病毒最早将于明年在患有恶性肿瘤的人身上进行测试。
来源:纽约邮报

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